Mouse Noggin/NOG protein (Recombinant) (C-His) (STJP001303)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse Noggin/NOG Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln28-Cys232) of mouse Noggin (Accession #NP_032737.1) fused with an 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Mouse Noggin/NOG-C-His protein was developed in hek293 cells using the region Gln28-Cys232. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | 1.Measured by its binding ability in a functional ELISA.Immobilized Human BMP4 at 0.5 Mu g/mL (100 Mu L/well) can bind Noggin with a linear range of 4-29 ng/mL.|2.Measured by its binding ability in a functional ELISA.Immobilized Human Noggin at 1 Mu |
| Determination Method | ＜1 EU/Mu g |
Target Information
| Gene Symbol | Nog |
| Gene ID | 18121 |
| Uniprot ID | NOGG_MOUSE |
| Immunogen | Recombinant Mouse Noggin/NOG Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln28-Cys232) of mouse Noggin (Accession #NP_032737.1) fused with an 6×His tag at the C-terminus. |
| Immunogen Region | Gln28-Cys232 |
| Immunogen Sequence | QHYLHIRPAPSDNLPLVDLI EHPDPIFDPKEKDLNETLLR SLLGGHYDPGFMATSPPEDR PGGGGGPAGGAEDLAELDQL LRQRPSGAMPSEIKGLEFSE GLAQGKKQRLSKKLRRKLQM WLWSQTFCPVLYAWNDLGSR FWPRYVKVGSCFSKRSCSVP EGMVCKPSKSVHLTVLRWRC QRRGGQRCGWIPIQYPIISE CKCSC |
Additional Info
| Function | Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6. |
| Protein Name | Noggin |
| Database Links | Reactome: R-MMU-201451 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Noggin proteinNog protein |
Information sourced from Uniprot.org