| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
＜1 EU/Mu g |
| Immunoreactivity: |
1.Measured by its binding ability in a functional ELISA.Immobilized Human BMP4 at 0.5 Mu g/mL (100 Mu L/well) can bind Noggin with a linear range of 4-29 ng/mL.|2.Measured by its binding ability in a functional ELISA.Immobilized Human Noggin at 1 Mu |
| Gene Symbol: |
Nog |
| Gene ID: |
18121 |
| Uniprot ID: |
NOGG_MOUSE |
| Immunogen: |
Recombinant Mouse Noggin/NOG Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln28-Cys232) of mouse Noggin (Accession #NP_032737.1) fused with an 6×His tag at the C-terminus. |
| Immunogen Sequence: |
QHYLHIRPAPSDNLPLVDLI EHPDPIFDPKEKDLNETLLR SLLGGHYDPGFMATSPPEDR PGGGGGPAGGAEDLAELDQL LRQRPSGAMPSEIKGLEFSE GLAQGKKQRLSKKLRRKLQM WLWSQTFCPVLYAWNDLGSR FWPRYVKVGSCFSKRSCSVP EGMVCKPSKSVHLTVLRWRC QRRGGQRCGWIPIQYPIISE CKCSC |
| Function | Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6. |
| Protein Name | Noggin |
| Database Links | Reactome: R-MMU-201451 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Noggin proteinNog protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
