Mouse NOG/Noggin protein (Recombinant-Active) (C-10*His) (STJP012051)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Active-Mouse NOG/Noggin-C-10*His protein was developed from mammalian cells and has a target region of C-10*His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by mouse chondrogenic cells (ATDC5). The ED50 for this effect is 0.06-0.3 µg/mL in the presence of 50 ng/mL of recombinant human BMP-4. |
Target Information
| Gene Symbol | Nog |
| Gene ID | 18121 |
| Uniprot ID | NOGG_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Leu20-Cys232 |
Additional Info
| Function | Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6. |
| Protein Name | Noggin |
| Database Links | Reactome: R-MMU-201451 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Noggin proteinNog protein |
Information sourced from Uniprot.org