| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
<0.1 EU/Mu g |
| Immunoreactivity: |
Measured by the ability of the immobilized protein to support the adhesion of NIH 3T3 mouse embryonic fibroblast cells. When 5 x 104 cells/well are added to recombinant mouse Nectin-4 coated plates (10 Mu g/mL with 100 Mu L/well) , approximately 30%- |
| Gene Symbol: |
Nectin4 |
| Gene ID: |
71740 |
| Uniprot ID: |
NECT4_MOUSE |
| Immunogen: |
Recombinant Mouse Nectin-4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly31-Ser347) of mouse Nectin-4 (Accession #NP_082169.2) fused with a 6ÃHis tag at the C-terminus. |
| Immunogen Sequence: |
GELETSDVVTVVLGQDAKLP CFYRGDPDEQVGQVAWARVD PNEGIRELALLHSKYGLHVN PAYEDRVEQPPPPRDPLDGS VLLRNAVQADEGEYECRVST FPAGSFQARMRLRVLVPPLP SLNPGPPLEEGQGLTLAASC TAEGSPAPSVTWDTEVKGTQ SSRSFTHPRSAAVTSEFHLV PSRSMNGQPLTCVVSHPGLL QDRRITHTLQVAFLAEASVR GLEDQNLWQVGREGATLKC |
| Function | Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Plays a role in the senescence-associated cell size enlargement via SFK/PI3K/Rac1 and thus promotes senescent cell survival. Participates also in the innate immune response by acting as a ligand for the receptor TIGIT to inhibit NK-cell activity. |
| Protein Name | Nectin-4Ig Superfamily Receptor LnirNectin Cell Adhesion Molecule 4Poliovirus Receptor-Related Protein 4 |
| Database Links | Reactome: R-MMU-418990Reactome: -MMU-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionAdherens JunctionColocalizes With Afdn At Cadherin-Based Adherens Junctions |
| Alternative Protein Names | Nectin-4 proteinIg Superfamily Receptor Lnir proteinNectin Cell Adhesion Molecule 4 proteinPoliovirus Receptor-Related Protein 4 proteinNectin4 proteinLnir proteinPrr4 proteinPvrl4 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
