Tissue Specificity | Expressed in B-cells that have been induced to switch to various Ig isotypes. |
Post Translational Modifications | Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group. Symmetrically methylated by PRMT5. |
Function | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. |
Protein Name | NucleolinProtein C23 |
Database Links | Reactome: R-MMU-6791226 |
Cellular Localisation | NucleusNucleolusCytoplasmLocalized In Cytoplasmic Mrnp Granules Containing Untranslated Mrnas |
Alternative ELISA Names | Nucleolin ELISA kitProtein C23 ELISA kitNcl ELISA kitNuc ELISA kit |
output | |
Information sourced from Uniprot.org