| Tissue Specificity | Expressed specifically in developing and adult skeletal muscle. Weak expression in adipose tissue. |
| Post Translational Modifications | Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase. |
| Function | Acts specifically as a negative regulator of skeletal muscle growth. |
| Protein Name | Growth/Differentiation Factor 8Gdf-8Myostatin |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Growth/Differentiation Factor 8 ELISA kitGdf-8 ELISA kitMyostatin ELISA kitMstn ELISA kitGdf8 ELISA kit |
| output | |
Information sourced from Uniprot.org
