| Short Description : | Recombinant-Mouse MMP-9-His-Tag protein was developed from hek293 cells and has a target region of His-Tag. For use in research applications. |
| Applications: | SDS-PAGE/Enzyme Activity |
| Host: | HEK293 Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Concentration: | 1 mg/mL |
| Formulation: | Liquid in 20mM Tris-HCl (pH 7.5) containing 1mM CaCl2, 100mM NaCl, 10% Glycerol |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin: | < 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity: | Specific activity is >1, 500 pmol/min/ug, and is defined as the amount of enzyme that cleaves 1pmol of Mca-PLGL-Dpa-AR-NH2 per minute at pH 7.5 at 25C. |
| Gene Symbol: | Mmp9 |
| Gene ID: | 17395 |
| Uniprot ID: | MMP9_MOUSE |
| Accession Number: | NP_038627.1 |
| Immunogen: | Mouse |
| Immunogen Region: | 20-730aa |
| Immunogen Sequence: | APYQRQPTFV VFPKDLKTSN LTDTQLAEAY LYRYGYTRAA QMMGEKQSLR PALLMLQKQL SLPQTGELDS QTLKAIRTPR CGVPDVGRFQ TFKGLKWDHH NITYWIQNYS EDLPRDMIDD AFARAFAVWG EVAPLTFTRV YGPEADIVIQ FGVAEHGDGY PFDGKDGLLA HAFPPGAGVQ GDAHFDDDEL WSLGKGVVIP TYYGNSNGAP CHFPFTFEGR SYSACTTD |
| Post Translational Modifications | N- and O-glycosylated. |
| Function | Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves NINJ1 to generate the Secreted ninjurin-1 form. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. |
| Protein Name | Matrix Metalloproteinase-9Mmp-992 Kda Gelatinase92 Kda Type Iv CollagenaseGelatinase BGelb |
| Database Links | Reactome: R-MMU-1433557Reactome: -MMU-1442490Reactome: -MMU-1474228Reactome: -MMU-1592389Reactome: -MMU-2022090Reactome: -MMU-3928665Reactome: -MMU-6798695Reactome: -MMU-9009391 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Matrix Metalloproteinase-9 proteinMmp-9 protein92 Kda Gelatinase protein92 Kda Type Iv Collagenase proteinGelatinase B proteinGelb proteinMmp9 proteinClg4b protein |
Information sourced from Uniprot.org
