Tissue Specificity | Mammary epithelial cell surfaces and spermatozoan. Isoform 2 is present in brain, heart, kidney and spleen and at low levels in lung, liver, small intestine and testis. |
Post Translational Modifications | N-glycosylated. Isoform 1 also exists in both an O-glycosylated and a non-O-glycosylated form. |
Function | Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. |
Protein Name | LactadherinMfgmMilk Fat Globule-Egf Factor 8Mfg-E8Sed1Sperm Surface Protein Sp47Mp47 |
Database Links | Reactome: R-MMU-381426Reactome: -MMU-8957275 |
Cellular Localisation | MembranePeripheral Membrane ProteinSecretedCytoplasmic VesicleSecretory VesicleAcrosome MembraneLocated In The Acrosomal Region Of Zona-Pellucida Bound Sperm |
Alternative ELISA Names | Lactadherin ELISA kitMfgm ELISA kitMilk Fat Globule-Egf Factor 8 ELISA kitMfg-E8 ELISA kitSed1 ELISA kitSperm Surface Protein Sp47 ELISA kitMp47 ELISA kitMfge8 ELISA kit |
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Information sourced from Uniprot.org