| Tissue Specificity | Expressed in osteocytes (at protein level). Expressed by chondrocytes, specifically in the hypertrophic zone of the bone growth plate (at protein level). Expressed in osteoblasts in bone (at protein level). Expressed by osteoblasts within the metaphysis (at protein level). Expressed at low levels in white fat, brown fat, testes, brain and aorta. Expressed in the craniofacial complex (at protein level). Expressed in odontoblasts, ameloblasts and in predentin during tooth development (at protein level). Expressed in the kidney (at protein level). Expressed in osteocytes in mandibular condylar cartilage and tibial cartilage (at protein level). Expressed in salivary glands. |
| Post Translational Modifications | Phosphorylated on serine residues in the ASARM motif.the phosphorylation is important for the inhibition of bone mineralization. Cleaved by CTSB/cathepsin B.the cleavage is blocked by metalloprotease PHEX. |
| Function | Regulates renal phosphate and uric acid excretion. Regulates bone mineralization by osteoblasts and cartilage mineralization by chondrocytes. Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage. Increases dental pulp stem cell proliferation. |
| Protein Name | Matrix Extracellular PhosphoglycoproteinOsteoblast/Osteocyte Factor 45Of45Osteoregulin |
| Database Links | Reactome: R-MMU-381426Reactome: -MMU-8957275 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative ELISA Names | Matrix Extracellular Phosphoglycoprotein ELISA kitOsteoblast/Osteocyte Factor 45 ELISA kitOf45 ELISA kitOsteoregulin ELISA kitMepe ELISA kit |
| output | |
Information sourced from Uniprot.org
