Mouse MECP2 (Methyl CpG Binding Protein 2) Sandwich ELISA Kit Kit (STJE0010552)

Mouse MECP2 (Methyl CpG Binding Protein 2) Sandwich ELISA Kit Kit (STJE0010552)

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STJE0010552
£476.50 - £651.50
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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.102ng/mL
Detection Limit: 0.312-20ng/mL
Short Description : This MECP2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates, cell lysates or other biological fluids..
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Mecp2
Gene ID: 17257
Uniprot ID: MECP2_MOUSE
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylated on Ser-421 by CaMK2 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation. Does not seem to be phosphorylated on Ser-421 in other tissues.
Function Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Protein Name Methyl-Cpg-Binding Protein 2
Mecp-2 Protein
Mecp2
Database Links Reactome: R-MMU-9022692 Q9Z2D6-1
Cellular Localisation Nucleus
Colocalized With Methyl-Cpg In The Genome
Colocalized With Tbl1x To The Heterochromatin Foci
Alternative ELISA Names Methyl-Cpg-Binding Protein 2 ELISA kit
Mecp-2 Protein ELISA kit
Mecp2 ELISA kit
Mecp2 ELISA kit
output

Information sourced from Uniprot.org

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