| Tissue Specificity | |
| Post Translational Modifications | Cleaved by CASP3 during apoptosis, yielding a pro-apoptotic C-terminal fragment. Rapidly degraded in the absence of phosphorylation in the PEST region. Phosphorylated on Ser-140, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-140 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites. Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-140. Deubiquitinated by USP20.leading to increased stability. |
| Function | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity. |
| Protein Name | Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 HomologBcl-2-Related Protein Eat/Mcl1 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Membrane ProteinCytoplasmMitochondrionNucleusNucleoplasmCytoplasmicAssociated With Mitochondria |
| Alternative ELISA Names | Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Homolog ELISA kitBcl-2-Related Protein Eat/Mcl1 ELISA kitMcl1 ELISA kit |
| output | |
Information sourced from Uniprot.org
