Function | Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. |
Protein Name | Mannose-Binding Protein CMbp-CMannan-Binding ProteinRa-Reactive Factor P28a SubunitRarf/P28a |
Database Links | Reactome: R-MMU-166662Reactome: -MMU-166663 |
Cellular Localisation | Secreted |
Alternative Protein Names | Mannose-Binding Protein C proteinMbp-C proteinMannan-Binding Protein proteinRa-Reactive Factor P28a Subunit proteinRarf/P28a proteinMbl2 protein |
Information sourced from Uniprot.org