Mouse LY6E/SCA-2 protein (Recombinant) (C-Fc) (STJP009532)

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STJP009532
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse LY6E/SCA-2-C-Fc protein was developed from mammalian cells and has a target region of C-Fc. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Ly6e
Gene ID: 17069
Uniprot ID: LY6E_MOUSE
Immunogen Region: Val24-Ala108
Immunogen: Mus musculus (Mouse)
Function GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of murine coronavirus, mouse hepatitis virus, by interfering with spike protein-mediated membrane fusion. Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response.
Protein Name Lymphocyte Antigen 6e
Ly-6e
Stem Cell Antigen 2
Thymic Shared Antigen 1
Tsa-1
Database Links Reactome: R-MMU-163125
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Alternative Protein Names Lymphocyte Antigen 6e protein
Ly-6e protein
Stem Cell Antigen 2 protein
Thymic Shared Antigen 1 protein
Tsa-1 protein
Ly6e protein
Ly67 protein
Sca-2 protein
Tsa-1 protein

Information sourced from Uniprot.org

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