| Tissue Specificity | |
| Post Translational Modifications | Phosphorylation at Ser-416 inhibits leukotriene-A4 hydrolase activity. |
| Function | Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4). Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides. In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions. |
| Protein Name | Leukotriene A-4 HydrolaseLta-4 HydrolaseLeukotriene A(4 HydrolaseTripeptide Aminopeptidase Lta4h |
| Database Links | Reactome: R-MMU-2142691Reactome: -MMU-6798695Reactome: -MMU-9018676Reactome: -MMU-9018681Reactome: -MMU-9018896Reactome: -MMU-9020265Reactome: -MMU-9023661 |
| Cellular Localisation | Cytoplasm |
| Alternative ELISA Names | Leukotriene A-4 Hydrolase ELISA kitLta-4 Hydrolase ELISA kitLeukotriene A(4 Hydrolase ELISA kitTripeptide Aminopeptidase Lta4h ELISA kitLta4h ELISA kit |
| output | |
Information sourced from Uniprot.org
