Tissue Specificity | Expressed at low levels in most tissues. High level expression is found in hepatocytes and splenic and thymic cells. Very high level expression is observed in cells of the small intestinal villi, the zona fasciculata and reticularis of the adrenal cortex, pancreatic acini, and renal tubular epithelium. |
Post Translational Modifications | Glycosylation is not essential for catalytic activity. |
Function | Catalyzes the deacylation of cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. Hydrolyzes triglycerides (1,2,3-triacylglycerol) and diglycerides (such as 1,2-diacylglycerol and 1,3-diacylglycerol) with preference for the acyl moieties at the sn-1 or sn-3 positions. |
Protein Name | Lysosomal Acid Lipase/Cholesteryl Ester HydrolaseAcid Cholesteryl Ester HydrolaseLalCholesteryl EsteraseDiacylglycerol LipaseLipase ASterol EsteraseTriacylglycerol Ester HydrolaseTriacylglycerol Lipase |
Database Links | Reactome: R-MMU-8964038 |
Cellular Localisation | Lysosome |
Alternative ELISA Names | Lysosomal Acid Lipase/Cholesteryl Ester Hydrolase ELISA kitAcid Cholesteryl Ester Hydrolase ELISA kitLal ELISA kitCholesteryl Esterase ELISA kitDiacylglycerol Lipase ELISA kitLipase A ELISA kitSterol Esterase ELISA kitTriacylglycerol Ester Hydrolase ELISA kitTriacylglycerol Lipase ELISA kitLipa ELISA kitLip1 ELISA kit |
output | |
Information sourced from Uniprot.org