Mouse LILRB4/CD85k/ILT3 protein (Recombinant) (C-6His) (STJP002878)

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STJP002878
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: <0.1 EU/Mu g
Gene Symbol: Lilrb4a
Gene ID: 14728
Uniprot ID: LRB4A_MOUSE
Immunogen Region: Gly24-Lys238
Immunogen: Recombinant Mouse LILRB4/CD85k/ILT3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Lys238) of mouse LILRB4 (Accession #NP_038560.1) fused with and a 6×His tag at the C-terminus.
Immunogen Sequence: GHLPKPIIWAEPGSVIAAYT SVITWCQGSWEAQYYHLYKE KSVNPWDTQVPLETRNKAKF NIPSMTTSYAGIYKCYYESA AGFSEHSDAMELVMTGAYEN PSLSVYPSSNVTSGVSISFS CSSSIVFGRFILIQEGKHGL SWTLDSQHQANQPSYATFVL DAVTPNHNGTFRCYGYFRNE PQVWSKPSNSLDLMISETKD QSSTPTEDGLETYQK
Post Translational Modifications Tyrosine phosphorylated.
Function Inhibitory receptor involved in the down-regulation of the immune response. Receptor for FN1. Receptor for integrin ITGAV/ITGB3. Inhibits IgE-mediated mast cell activation, at least in part through interaction with ITGAV/ITGB3. Also inhibits KITLG/SCF-mediated mast cell activation. Through interaction with ITGAV/ITGB3, inhibits antibody production by memory and marginal zone B cells, probably by suppressing their differentiation into plasma cells. Inhibits IFNG production by CD8 T cells, CD4 T cells and natural killer cells. Inhibits antigen presentation by dendritic cells to T cells, preventing T cell activation. Inhibits lipopolysaccharide-mediated neutrophil-dependent vascular injury. Suppresses the allergic inflammatory response by inhibiting infiltration of neutrophils and eosinophils and preventing mast cell degranulation. Inhibits lysis by natural killer cells.
Protein Name Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4a
Mast Cell Surface Glycoprotein Gp49b
Cd Antigen Cd85k
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4a protein
Mast Cell Surface Glycoprotein Gp49b protein
Cd Antigen Cd85k protein
Lilrb4a protein
Gp49b protein

Information sourced from Uniprot.org

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