| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
<0.1 EU/Mu g |
| Gene Symbol: |
Lilrb4a |
| Gene ID: |
14728 |
| Uniprot ID: |
LRB4A_MOUSE |
| Immunogen Region: |
Gly24-Lys238 |
| Immunogen: |
Recombinant Mouse LILRB4/CD85k/ILT3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Lys238) of mouse LILRB4 (Accession #NP_038560.1) fused with and a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
GHLPKPIIWAEPGSVIAAYT SVITWCQGSWEAQYYHLYKE KSVNPWDTQVPLETRNKAKF NIPSMTTSYAGIYKCYYESA AGFSEHSDAMELVMTGAYEN PSLSVYPSSNVTSGVSISFS CSSSIVFGRFILIQEGKHGL SWTLDSQHQANQPSYATFVL DAVTPNHNGTFRCYGYFRNE PQVWSKPSNSLDLMISETKD QSSTPTEDGLETYQK |
| Post Translational Modifications | Tyrosine phosphorylated. |
| Function | Inhibitory receptor involved in the down-regulation of the immune response. Receptor for FN1. Receptor for integrin ITGAV/ITGB3. Inhibits IgE-mediated mast cell activation, at least in part through interaction with ITGAV/ITGB3. Also inhibits KITLG/SCF-mediated mast cell activation. Through interaction with ITGAV/ITGB3, inhibits antibody production by memory and marginal zone B cells, probably by suppressing their differentiation into plasma cells. Inhibits IFNG production by CD8 T cells, CD4 T cells and natural killer cells. Inhibits antigen presentation by dendritic cells to T cells, preventing T cell activation. Inhibits lipopolysaccharide-mediated neutrophil-dependent vascular injury. Suppresses the allergic inflammatory response by inhibiting infiltration of neutrophils and eosinophils and preventing mast cell degranulation. Inhibits lysis by natural killer cells. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4aMast Cell Surface Glycoprotein Gp49bCd Antigen Cd85k |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4a proteinMast Cell Surface Glycoprotein Gp49b proteinCd Antigen Cd85k proteinLilrb4a proteinGp49b protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
