Tissue Specificity | Detected in the four cardiac valves, valvular interstitial cells and extracellular matrix (at protein level). |
Post Translational Modifications | After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein. |
Function | Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization. |
Protein Name | Leukocyte Cell-Derived Chemotaxin 1Chondromodulin Cleaved Into - Chondrosurfactant ProteinCh-Sp - Chondromodulin-1Chondromodulin-IChm-I |
Database Links | |
Cellular Localisation | Chondromodulin-1: SecretedExtracellular SpaceExtracellular MatrixAccumulated In The Inter-Territorial Matrix Of CartilageChondrosurfactant Protein: Endomembrane SystemSingle-Pass Membrane Protein |
Alternative ELISA Names | Leukocyte Cell-Derived Chemotaxin 1 ELISA kitChondromodulin Cleaved Into - Chondrosurfactant Protein ELISA kitCh-Sp - Chondromodulin-1 ELISA kitChondromodulin-I ELISA kitChm-I ELISA kitCnmd ELISA kitChmi ELISA kitLect1 ELISA kit |
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Information sourced from Uniprot.org