Tissue Specificity | Expressed in skin and, at lower levels, in lung, kidney, brain, heart and spleen. In skin, expressed in high suprabasal keratinocytes and in the luminal parts of hair follicles. Not detected in liver and skeletal muscle. |
Post Translational Modifications | |
Function | May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. |
Protein Name | Kallikrein-7Serine Protease 6Stratum Corneum Chymotryptic EnzymeThymopsin |
Database Links | Reactome: R-MMU-1474228 |
Cellular Localisation | Secreted |
Alternative ELISA Names | Kallikrein-7 ELISA kitSerine Protease 6 ELISA kitStratum Corneum Chymotryptic Enzyme ELISA kitThymopsin ELISA kitKlk7 ELISA kitPrss6 ELISA kitScce ELISA kit |
output | |
Information sourced from Uniprot.org