Mouse KLF1 (Kruppel Like Factor 1, Erythroid) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016561)

Mouse KLF1 (Kruppel Like Factor 1, Erythroid) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016561)

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STJE0016561
£496.50 - £681.50
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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 5.8pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description : This KLF1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse serum, plasma or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Klf1
Uniprot ID: KLF1_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma or other biological fluids.
Tissue Specificity Erythroid-specific. Only expressed in bone marrow and spleen.
Post Translational Modifications Acetylated.can be acetylated on both Lys-270 and Lys-288. Acetylation on Lys-270 (by CBP) appears to be the major site affecting EKLF transactivation activity. Sumoylated.sumoylation, promoted by PIAS1, leads to repression of megakaryocyte differentiation. Also promotes the interaction with the CDH4 subunit of the NuRD repression complex. Phosphorylated primarily on serine residues in the transactivation domain. Phosphorylation on Thr-23 is critical for the transactivation activity.
Function Transcription regulator of erythrocyte development. Binds to the CACCC box in the beta-globin gene promoter and activates transcription. Probably serves as a general switch factor for erythroid development. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
Protein Name Krueppel-Like Factor 1
Erythroid Krueppel-Like Transcription Factor
Eklf
Database Links
Cellular Localisation Nucleus
Colocalizes With Sumo1 In Nuclear Speckles
Alternative ELISA Names Krueppel-Like Factor 1 ELISA kit
Erythroid Krueppel-Like Transcription Factor ELISA kit
Eklf ELISA kit
Klf1 ELISA kit
Elkf ELISA kit
output

Information sourced from Uniprot.org

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