| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. May be involved in the mechanisms of growth arrest induced by exposure to DNA-damaging drugs or by cellular senescence. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends. Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells. |
| Protein Name | Kinesin-1 Heavy ChainConventional Kinesin Heavy ChainUbiquitous Kinesin Heavy ChainUkhc |
| Database Links | Reactome: R-MMU-2132295Reactome: -MMU-5625970Reactome: -MMU-6811434Reactome: -MMU-983189 |
| Cellular Localisation | CytoplasmCytoskeletonCytolytic Granule MembraneLysosome MembranePeripheral Membrane ProteinCytoplasmic SideUniformly Distributed Between Soma And Neurites In Hippocampal Neurons |
| Alternative ELISA Names | Kinesin-1 Heavy Chain ELISA kitConventional Kinesin Heavy Chain ELISA kitUbiquitous Kinesin Heavy Chain ELISA kitUkhc ELISA kitKif5b ELISA kitKhcs ELISA kitKns1 ELISA kit |
| output | |
Information sourced from Uniprot.org
