| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 29.4pg/mL |
| Detection Limit: | 78.1-5000pg/mL |
| Short Description : | This KIF5B Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | Kif5b |
| Gene ID: | 16573 |
| Uniprot ID: | KINH_MOUSE |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. May be involved in the mechanisms of growth arrest induced by exposure to DNA-damaging drugs or by cellular senescence. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends. Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells. |
| Protein Name | Kinesin-1 Heavy Chain Conventional Kinesin Heavy Chain Ubiquitous Kinesin Heavy Chain Ukhc |
| Database Links | Reactome: R-MMU-2132295 Reactome: -MMU-5625970 Reactome: -MMU-6811434 Reactome: -MMU-983189 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cytolytic Granule Membrane Lysosome Membrane Peripheral Membrane Protein Cytoplasmic Side Uniformly Distributed Between Soma And Neurites In Hippocampal Neurons |
| Alternative ELISA Names | Kinesin-1 Heavy Chain ELISA kit Conventional Kinesin Heavy Chain ELISA kit Ubiquitous Kinesin Heavy Chain ELISA kit Ukhc ELISA kit Kif5b ELISA kit Khcs ELISA kit Kns1 ELISA kit |
| output |
Information sourced from Uniprot.org