| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
30pg/mL |
| Detection Limit: |
78.1-5000pg/mL |
| Short Description: |
This KIBRA Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates, cell lysates or other biological fluids. |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Wwc1 |
| Gene ID: |
211652 |
| Uniprot ID: |
KIBRA_MOUSE |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Mammary epithelium. |
| Post Translational Modifications | Phosphorylation at Ser-542 and Ser-923 by CDK1 in response to spindle damage stress regulates mitotic exit, these two sites are dephosphorylated by CDC14B. |
| Function | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Modulates directional migration of podocytes. May be associated with memory performance. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking. |
| Protein Name | Protein KibraKidney And Brain ProteinKibraWw Domain-Containing Protein 1 |
| Database Links | Reactome: R-MMU-2028269 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusCell ProjectionRuffle MembraneCytosolColocalizes With Prkcz In The Perinuclear Region |
| Alternative ELISA Names | Protein Kibra ELISA kitKidney And Brain Protein ELISA kitKibra ELISA kitWw Domain-Containing Protein 1 ELISA kitWwc1 ELISA kitKiaa0869 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
