Mouse JAM-A/F11R/CD321 protein (Recombinant) (C-His) (STJP020296)

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STJP020296-100
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: F11r
Gene ID: 16456
Uniprot ID: JAM1_MOUSE
Immunogen Region: Lys27-Gly238
Immunogen: Recombinant Mouse JAM-A/F11R/CD321 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys27-Gly238) of mouse JAM-A/F11R/CD321 (Accession #O88792) fused with His tag at the C-terminus.
Function Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation.
Protein Name Junctional Adhesion Molecule A
Jam-A
Junctional Adhesion Molecule 1
Jam-1
Cd Antigen Cd321
Database Links Reactome: R-MMU-202733
Reactome: -MMU-216083
Reactome: -MMU-2173791
Reactome: -MMU-420029
Cellular Localisation Cell Junction
Tight Junction
Cell Membrane
Single-Pass Type I Membrane Protein
Localized At Tight Junctions Of Both Epithelial And Endothelial Cells
Alternative Protein Names Junctional Adhesion Molecule A protein
Jam-A protein
Junctional Adhesion Molecule 1 protein
Jam-1 protein
Cd Antigen Cd321 protein
F11r protein
Jam1 protein
Jcam protein
Jcam1 protein

Information sourced from Uniprot.org

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