Tissue Specificity | |
Post Translational Modifications | |
Function | Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. |
Protein Name | Inosine Triphosphate PyrophosphataseItpaseInosine TriphosphataseNon-Canonical Purine Ntp PyrophosphataseNon-Standard Purine Ntp PyrophosphataseNucleoside-Triphosphate DiphosphataseNucleoside-Triphosphate PyrophosphataseNtpase |
Database Links | Reactome: R-MMU-74259Reactome: -MMU-9755088 |
Cellular Localisation | Cytoplasm |
Alternative ELISA Names | Inosine Triphosphate Pyrophosphatase ELISA kitItpase ELISA kitInosine Triphosphatase ELISA kitNon-Canonical Purine Ntp Pyrophosphatase ELISA kitNon-Standard Purine Ntp Pyrophosphatase ELISA kitNucleoside-Triphosphate Diphosphatase ELISA kitNucleoside-Triphosphate Pyrophosphatase ELISA kitNtpase ELISA kitItpa ELISA kit |
output | |
Information sourced from Uniprot.org