Mouse IL21 protein (Recombinant-Active) (No tag) (STJP012257)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Active-Mouse IL21-No tag protein was developed from mammalian cells and has a target region of No tag. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to enhance IFN-gamma secretion in human natural killer lymphoma cells (NK-92). The ED50 for this effect is 3-30 ng/mL. |
Target Information
| Gene Symbol | Il21 |
| Gene ID | 60505 |
| Uniprot ID | IL21_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Pro25-Ser146 |
Additional Info
| Function | Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. |
| Protein Name | Interleukin-21Il-21 |
| Database Links | Reactome: R-MMU-9020958 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-21 proteinIl-21 proteinIl21 protein |
Information sourced from Uniprot.org