| Host: | Mammalian Cells |
| Applications: | ELISA/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Active-Mouse IL1RL2/IL-36R-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilised rmIL-1F5, rmIL-1F6, or rmIL-1F8 at 1 µg/mL (100 µL/well) can bind rmIL1RL2/IL-36R with a linear range of 0.078-5 µg/mL. |
| Gene Symbol: | Il1rl2 |
| Gene ID: | 107527 |
| Uniprot ID: | ILRL2_MOUSE |
| Immunogen Region: | Asp22-Arg338 |
| Immunogen: | Mus musculus (Mouse) |
| Function | Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response.it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. |
| Protein Name | Interleukin-1 Receptor-Like 2Il-36 ReceptorInterleukin-1 Receptor-Related Protein 2Il-1rrp2Il1r-Rp2 |
| Database Links | Reactome: R-MMU-9007892Reactome: -MMU-9014826 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-1 Receptor-Like 2 proteinIl-36 Receptor proteinInterleukin-1 Receptor-Related Protein 2 proteinIl-1rrp2 proteinIl1r-Rp2 proteinIl1rl2 protein |
Information sourced from Uniprot.org
