Mouse IL11Ra (Interleukin 11 Receptor Alpha) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016141)

Mouse IL11Ra (Interleukin 11 Receptor Alpha) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016141)

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STJE0016141
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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.061ng/mL
Detection Limit: 0.156-10ng/mL
Short Description : This IL11Ra Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Il11ra1
Gene ID: 16157
Uniprot ID: I11RA_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Widely expressed in all adult tissues and in embryos. Highest levels in kidney, skeletal muscle and embryo.
Post Translational Modifications A short soluble form is also released from the membrane by proteolysis. The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing. mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3.
Function Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Soluble interleukin-11 receptor subunit alpha: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.
Protein Name Interleukin-11 Receptor Subunit Alpha-1
Il-11 Receptor Subunit Alpha-1
Il-11r Subunit Alpha-1
Il-11r-Alpha-1
Il-11ra1
Enhancer Trap Locus Homolog 2
Etl-2
Novel Cytokine Receptor 1
Nr-1
Nr1 Cleaved Into - Soluble Interleukin-11 Receptor Subunit Alpha
Sil-11r
Sil-11ra
Sil11ra
Database Links Reactome: R-MMU-6788467
Cellular Localisation Interleukin-11 Receptor Subunit Alpha-1: Membrane
Single-Pass Type I Membrane Protein
Secreted
Soluble Interleukin-11 Receptor Subunit Alpha: Secreted
Alternative ELISA Names Interleukin-11 Receptor Subunit Alpha-1 ELISA kit
Il-11 Receptor Subunit Alpha-1 ELISA kit
Il-11r Subunit Alpha-1 ELISA kit
Il-11r-Alpha-1 ELISA kit
Il-11ra1 ELISA kit
Enhancer Trap Locus Homolog 2 ELISA kit
Etl-2 ELISA kit
Novel Cytokine Receptor 1 ELISA kit
Nr-1 ELISA kit
Nr1 Cleaved Into - Soluble Interleukin-11 Receptor Subunit Alpha ELISA kit
Sil-11r ELISA kit
Sil-11ra ELISA kit
Sil11ra ELISA kit
Il11ra1 ELISA kit
Etl2 ELISA kit
Il11ra ELISA kit
output

Information sourced from Uniprot.org

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