Recombinant Mouse IL-21 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

Mouse IL-21 protein (Recombinant) (No tag) (STJP003064)

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STJP003064
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Host: E.coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: Il21
Gene ID: 60505
Uniprot ID: IL21_MOUSE
Immunogen Region: Ser21-Ser146
Immunogen: Recombinant Mouse IL-21 Protein is produced by CHO Cells expression system. The target protein is expressed with sequence (Ser21-Ser146) of Mouse IL-21 (Accession #NP_068554.1) fused with a His tag at the C-terminus.
Immunogen Sequence: FNLPLGNYKKPKLLYCSNGG HFLRILPDGTVDGTRDRSDQ HIQLQLSAESAGEVYIKGTE TGQYLAMDTEGLLYGSQTPN EECLFLERLEENHYNTYTSK KHAEKNWFVGLKKNGSCKRG PRTHYGQKAILFLPLPVSSD
Tissue Specificity Expressed in CD4(+) T cells.
Function Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Protein Name Interleukin-21
Il-21
Database Links Reactome: R-MMU-9020958
Cellular Localisation Secreted
Alternative Protein Names Interleukin-21 protein
Il-21 protein
Il21 protein

Information sourced from Uniprot.org

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