| Short Description : | Recombinant-Mouse IL-1Ra/IL1RN-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications: | SDS-PAGE/Bioactivity |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Concentration: | 1 mg/mL |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% Glycerol |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin: | < 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity: | Measured by its ability to inhibit proliferation using D10.G4.1 mouse helper T cells. The ED50 for this effect is less or equal to 60ng/ml with Mouse IL-1 alpha. |
| Gene Symbol: | Il1rn |
| Gene ID: | 16181 |
| Uniprot ID: | IL1RA_MOUSE |
| Accession Number: | NP_001034790 |
| Immunogen: | Mouse |
| Immunogen Region: | 27-178aa |
| Immunogen Sequence: |
| Function | Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens. |
| Protein Name | Interleukin-1 Receptor Antagonist ProteinIl-1rnIl-1raIrapIl1 Inhibitor |
| Database Links | Reactome: R-MMU-9020702 |
| Cellular Localisation | Isoform 1: SecretedIsoform 2: Cytoplasm |
| Alternative Protein Names | Interleukin-1 Receptor Antagonist Protein proteinIl-1rn proteinIl-1ra proteinIrap proteinIl1 Inhibitor proteinIl1rn proteinIl-1ra protein |
Information sourced from Uniprot.org