Mouse IL-13 alpha 2 receptor (IL13RA2) protein (Recombinant) (STJP000296)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenOptimized DNA sequence encoding extracellular domain of mouse IL-13 receptor alpha2 including an His tag was expressed in HEK293 cells. NA
General Information
| Short Description | Recombinant-Mouse IL-13 alpha 2 receptor (IL13RA2)-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised 0.2 Mu m filtered PBS solution, pH7.2. |
| Storage Instruction | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Immunoreactivity | The activity was measured by its ability to inhibit proliferation of IL-13 dependent TF1 Cells. The ED50 was determined to be 0.1-0.5 ug/ml. NA |
Target Information
| Gene Symbol | Il13ra2 |
| Gene ID | 16165 |
| Uniprot ID | I13R2_MOUSE |
| Immunogen | Optimized DNA sequence encoding extracellular domain of mouse IL-13 receptor alpha2 including an His tag was expressed in HEK293 cells. NA |
| Immunogen Region | ECD |
Additional Info
| Post Translational Modifications | Cleaved by MMP8 leading to a soluble form that is also able to interact with IL13. |
| Function | Cell surface receptor that plays a role in the regulation of IL-13-mediated responses. Functions as a decoy receptor that inhibits IL-13- and IL-4-mediated signal transduction via the JAK-STAT pathway and thereby modulates immune responses and inflammation. Serves as a functional signaling receptor for IL-13 in an alternative pathway involving AP-1 ultimately leading to the production of TGFB1. |
| Protein Name | Interleukin-13 Receptor Subunit Alpha-2Il-13 Receptor Subunit Alpha-2Il-13r Subunit Alpha-2Il-13r-Alpha-2Il-13ra2Cd Antigen Cd213a2 |
| Database Links | Reactome: R-MMU-6785807 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Protein Names | Interleukin-13 Receptor Subunit Alpha-2 proteinIl-13 Receptor Subunit Alpha-2 proteinIl-13r Subunit Alpha-2 proteinIl-13r-Alpha-2 proteinIl-13ra2 proteinCd Antigen Cd213a2 proteinIl13ra2 protein |
Information sourced from Uniprot.org