| Host: | Rabbit/Rabbit |
| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | This IL-12 p40 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Clonality : | Monoclonal/Monoclonal |
| Clone ID : | R03-1X8/R02-6Z7 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.01M PBS, pH 7.2 |
| Purification: | Affinity Purified |
| Concentration: | 1 mg/mL |
| Dilution Range: | Determined by end user |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | Il12b |
| Gene ID: | 16160 |
| Uniprot ID: | IL12B_MOUSE |
| Immunogen: | Recombinant protein |
| Function | Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
| Protein Name | Interleukin-12 Subunit BetaIl-12bCytotoxic Lymphocyte Maturation Factor 40 Kda SubunitClmf P40Il-12 Subunit P40 |
| Database Links | Reactome: R-MMU-9020591Reactome: -MMU-9020933 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Interleukin-12 Subunit Beta antibody pairIl-12b antibody pairCytotoxic Lymphocyte Maturation Factor 40 Kda Subunit antibody pairClmf P40 antibody pairIl-12 Subunit P40 antibody pairIl12b antibody pair |
Information sourced from Uniprot.org