| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g |
| Immunoreactivity: | Measured in a cell proliferation assay using TF-1 Human erythroleukemic cells. The ED50 for this effect is 2.64-10.56 ng/mL, corresponding to a specific activity of 9.47×104~3.79×105 units/mg. |
| Gene Symbol: | Il11 |
| Gene ID: | 16156 |
| Uniprot ID: | IL11_MOUSE |
| Immunogen Region: | Pro-Leu199 |
| Immunogen: | Recombinant mouse IL-11 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Pro-Leu199) of mouse IL-11 (Accession #) fused with additional amino acid free. |
| Immunogen Sequence: | PRVPITQNPCPPLKECPPCA APDLLGGPSVFIFPPKIKDV LMISLSPMVTCVVVDVSEDD PDVQISWFVNNVEVHTAQTQ THREDYNSTLRVVSALPIQH QDWMSGKEFKCKVNNRALPS PIEKTISKPRGPVRAPQVYV LPPPAEEMTKKEFSLTCMIT GFLPAEIAVDWTSNGRTEQN YKNTATVLDSDGSYFMYSKL RVQKSTWERGSLFACSVVHE GLHNHLTTKTISRSLGL |
| Function | Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. |
| Protein Name | Interleukin-11Il-11 |
| Database Links | Reactome: R-MMU-6788467 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-11 proteinIl-11 proteinIl11 protein |
Information sourced from Uniprot.org