| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
Recombinant Mouse IFN-beta enhances STAT1 autophosphorylation in Bone-marrow-derived macrophage (BMDM). 5-500 ng/mL of Recombinant Mouse IFN-beta can enhance STAT1 autophosphorylation. |
| Gene Symbol: |
Ifnb1 |
| Gene ID: |
15977 |
| Uniprot ID: |
IFNB_MOUSE |
| Immunogen Region: |
Ile22-Asn182 |
| Immunogen: |
Active Recombinant Mouse IFN-beta Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile22-Asn182) of mouse Interferon beta (Accession #NP_034640.1) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Sequence: |
INYKQLQLQERTNIRKCQEL LEQLNGKINLTYRADFKIPM EMTEKMQKSYTAFAIQEMLQ NVFLVFRNNFSSTGWNETIV VRLLDELHQQTVFLKTVLEE KQEERLTWEMSSTALHLKSY YWRVQRYLKLMKYNSYAWMV VRAEIFRNFLIIRRLTRNFQ N |
| Post Translational Modifications | This beta interferon does not have a disulfide bond. |
| Function | Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth. |
| Protein Name | Interferon BetaIfn-Beta |
| Database Links | Reactome: R-MMU-909733Reactome: -MMU-912694 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interferon Beta proteinIfn-Beta proteinIfnb1 proteinIfb proteinIfnb protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
