Tissue Specificity | Expressed at low level on a subpopulation of lymphocytes, macrophages, and endothelial cells, but is strongly induced on these cells, and on fibroblasts and epithelial cells. |
Post Translational Modifications | Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. |
Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. |
Protein Name | Intercellular Adhesion Molecule 1Icam-1Mala-2Myd10Cd Antigen Cd54 |
Database Links | Reactome: R-MMU-198933Reactome: -MMU-216083 |
Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
Alternative ELISA Names | Intercellular Adhesion Molecule 1 ELISA kitIcam-1 ELISA kitMala-2 ELISA kitMyd10 ELISA kitCd Antigen Cd54 ELISA kitIcam1 ELISA kitIcam-1 ELISA kit |
output | |
Information sourced from Uniprot.org