• Mouse ICAM-1/CD54 protein (Recombinant) (C-hFc&His) (STJP001136)

Mouse ICAM-1/CD54 protein (Recombinant) (C-hFc&His) (STJP001136)

SKU:
STJP001136

£80.50 - £257.50
Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by the ability of the immobilized protein to support the adhesion of THP-1 cells. When cells are added to ICAM-1 coated plates (12.5 Mu g/mL, 100 Mu L/well) , approximately >80% cells will adhere specifically after 60 minutes at 37 °C.
Gene Symbol: Icam1
Gene ID: 15894
Uniprot ID: ICAM1_MOUSE
Immunogen: Recombinant Mouse ICAM-1/CD54 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln28-Asn485) of mouse ICAM-1/CD54 (Accession #NP_034623.1. ) fused with an Fc, 6×His tag at the C-terminus.
Immunogen Sequence: QVSIHPREAFLPQGGSVQVN CSSSCKEDLSLGLETQWLKD ELESGPNWKLFELSEIGEDS SPLCFENCGTVQSSASATIT VYSFPESVELRPLPAWQQVG KDLTLRCHVDGGAPRTQLSA VLLRGEEILSRQPVGGHPKD PKEITFTVLASRGDHGANFS CRTELDLRPQGLALFSNVSE ARSLRTFDLPATIPKLDTPD LLEVGTQQKLFCSLEGLFPA SEARIYLELGGQMPTQEST
Post Translational Modifications Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
Function ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
Protein Name Intercellular Adhesion Molecule 1
Icam-1
Mala-2
Myd10
Cd Antigen Cd54
Database Links Reactome: R-MMU-198933
Reactome: -MMU-216083
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Intercellular Adhesion Molecule 1 protein
Icam-1 protein
Mala-2 protein
Myd10 protein
Cd Antigen Cd54 protein
Icam1 protein
Icam-1 protein

Information sourced from Uniprot.org

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