| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Supplied as a 0.22 Mu m filtered solution in 50 mM Tris-HCl, 150 mM NaCl, 2 mM DTT, pH 7.5. |
| Storage Instruction: | Store at-70 °C. This product is stable at ≤-70 °C for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | Hamp |
| Gene ID: | 84506 |
| Uniprot ID: | HEPC_MOUSE |
| Immunogen Region: | Asp59-Thr83 |
| Immunogen: | Recombinant Mouse Hepcidin/HAMP Protein is produced by E. coli expression system. The target protein is expressed with sequence (Asp59-Thr83) of mouse Hepcidin/HAMP (Accession #NP_115930.1) fused with GST tag at the N-terminus. |
| Immunogen Sequence: | DTNFPICIFCCKCCNNSQCG ICCKT |
| Tissue Specificity | Highly expressed in the liver and to a much lesser extent in the heart. Secreted in blood. |
| Function | Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes. |
| Protein Name | Hepcidin |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Hepcidin proteinHamp proteinHamp1 proteinHepc proteinHepc1 protein |
Information sourced from Uniprot.org
