| Tissue Specificity | Expressed in the intestinal epithelium. |
| Post Translational Modifications | N-glycosylated. O-glycosylated.contains chondroitin sulfate glycans which can be more or less sulfated. Phosphorylated.activation of PKC results in the dephosphorylation of Ser-742 (constitutive phosphorylation site), and the phosphorylation of Ser-708. |
| Function | Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion. |
| Protein Name | Cd44 AntigenExtracellular Matrix Receptor IiiEcmr-IiiGp90 Lymphocyte Homing/Adhesion ReceptorHutch-IHermes AntigenHyaluronate ReceptorLymphocyte Antigen 24Ly-24Phagocytic Glycoprotein 1Pgp-1Phagocytic Glycoprotein IPgp-ICd Antigen Cd44 |
| Database Links | Reactome: R-MMU-1474228Reactome: -MMU-202733Reactome: -MMU-216083Reactome: -MMU-2160916Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionMicrovillusSecretedColocalizes With Actin In Membrane Protrusionfs At Wounding EdgesCo-Localizes With RdxEzr And Msn In Microvilli |
| Alternative ELISA Names | Cd44 Antigen ELISA kitExtracellular Matrix Receptor Iii ELISA kitEcmr-Iii ELISA kitGp90 Lymphocyte Homing/Adhesion Receptor ELISA kitHutch-I ELISA kitHermes Antigen ELISA kitHyaluronate Receptor ELISA kitLymphocyte Antigen 24 ELISA kitLy-24 ELISA kitPhagocytic Glycoprotein 1 ELISA kitPgp-1 ELISA kitPhagocytic Glycoprotein I ELISA kitPgp-I ELISA kitCd Antigen Cd44 ELISA kitCd44 ELISA kitLy-24 ELISA kit |
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Information sourced from Uniprot.org
