Mouse GZMA/Granzyme A protein (Recombinant) (N-His) (STJP011099)

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STJP011099
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse GZMA/Granzyme A-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Gzma
Gene ID: 14938
Uniprot ID: GRAA_MOUSE
Immunogen Region: Val36-Val260
Immunogen: Mus musculus (Mouse)
Function Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
Protein Name Granzyme A
Autocrine Thymic Lymphoma Granzyme-Like Serine Protease
Ctla-3
Fragmentin-1
T Cell-Specific Serine Protease 1
Tsp-1
Cellular Localisation Secreted
Cytoplasmic Granule
Delivered Into The Target Cell By Perforin
Alternative Protein Names Granzyme A protein
Autocrine Thymic Lymphoma Granzyme-Like Serine Protease protein
Ctla-3 protein
Fragmentin-1 protein
T Cell-Specific Serine Protease 1 protein
Tsp-1 protein
Gzma protein
Ctla-3 protein
Ctla3 protein
Mtsp-1 protein

Information sourced from Uniprot.org

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