Mouse GATA4 protein (Recombinant) (N-GST & C-His) (STJP011119)

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STJP011119
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse GATA4-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Gata4
Gene ID: 14463
Uniprot ID: GATA4_MOUSE
Immunogen Region: Leu204-Ile314
Immunogen: Mus musculus (Mouse)
Post Translational Modifications Methylation at Lys-299 attenuates transcriptional activity.
Function Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development. May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase.
Protein Name Transcription Factor Gata-4
Gata-Binding Factor 4
Database Links Reactome: R-MMU-983231
Cellular Localisation Nucleus
Alternative Protein Names Transcription Factor Gata-4 protein
Gata-Binding Factor 4 protein
Gata4 protein
Gata-4 protein

Information sourced from Uniprot.org

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