| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Biotin |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Immunogen Region: | Ala18-Leu628 |
| Immunogen: | Biotinylated Recombinant Mouse GARP&Latent TGF beta 1 Complex Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Ala18-Leu628 (GARP) &Leu30-Ser390 (Latent TGF beta 1) ) of Mouse GARP&Latent TGF beta 1 fus |
| Background | GARP&Latent TGF Beta is a complex found on surface of many types of cells. In Tregs, GARP is involved in TCR-mediated activation of Latent TGF-Beta and thus promoting secretion and activation of TGF-Beta. Integrin Alpha v Beta 8 on the surface of immune cells and other cells recognizes RGD in LAP, resulting in the release of mature TGF-Beta from the TGF-Beta &GARP complex. |
Information sourced from Uniprot.org
