Biotinylated Mouse GARP&Latent TGF beta 1 Complex on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Mouse GARP&Latent TGF beta 1 Complex protein (Recombinant) (N-His-Avi) {Biotin} (STJP001603)

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STJP001603
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Short Description :Recombinant-Mouse GARP&Latent TGF beta 1 Complex-N-His-Avi protein was developed from hek293 and has a target region of N-His-Avi. For use in research applications.
Host:HEK293
Note:STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Biotin
Dilution Range:Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Formulation:Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Storage Instruction:The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin:Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol:Lrrc32
Gene ID:434215
Uniprot ID:LRC32_MOUSE
Immunogen:DNA sequence encoding Mouse GARP&Latent TGF beta 1 Complex including a N-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Immunogen Region:Ala18-Leu628 (GARP) & Leu30-Ser390 (Latent TGF beta 1)
Function Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3).
Protein Name Transforming Growth Factor Beta Activator Lrrc32
Garpin
Glycoprotein A Repetitions Predominant
Garp
Leucine-Rich Repeat-Containing Protein 32
Database Links
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Surface
Alternative Protein Names Transforming Growth Factor Beta Activator Lrrc32 protein
Garpin protein
Glycoprotein A Repetitions Predominant protein
Garp protein
Leucine-Rich Repeat-Containing Protein 32 protein
Lrrc32 protein

Information sourced from Uniprot.org

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