| Host: | Goat/Goat |
| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: | This FGF23 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Clonality: | Polyclonal/Polyclonal |
| Conjugation: | Unconjugated/Biotin |
| Formulation: | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Purification: | Capture Purification: Antigen Affinity.Detection Purification: Antigen Affinity. |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: | Fgf23 |
| Gene ID: | 64654 |
| Uniprot ID: | FGF23_MOUSE |
| Immunogen: | Capture immunogen: Recombinant Mouse FGF23 protein.Detection Immunogen: Recombinant Mouse FGF23 protein. |
| Post Translational Modifications | Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases. O-glycosylated at Thr-171 and Thr-178 by GALNT3 and glycosylation of Thr-178 requires previous glycosylation at Thr171. Glycosylation is necessary for secretion.it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23. Phosphorylation at Ser-180 mediated by FAM20C slows down glycosylation at Thr-178 notably. |
| Function | Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblasts differentiation and matrix mineralization. Up-regulates EGR1 expression in the presence of KL. |
| Protein Name | Fibroblast Growth Factor 23Fgf-23 |
| Database Links | Reactome: R-MMU-109704Reactome: -MMU-1257604Reactome: -MMU-190322Reactome: -MMU-190372Reactome: -MMU-190373Reactome: -MMU-190374Reactome: -MMU-190375Reactome: -MMU-381426Reactome: -MMU-5654219Reactome: -MMU-5654221Reactome: -MMU-5654227Reactome: -MMU-5654228Reactome: -MMU-5654687Reactome: -MMU-5654688Reactome: -MMU-5654689Reactome: -MMU-5654693Reactome: -MMU-5654695Reactome: -MMU-5654699Reactome: -MMU-5654700Reactome: -MMU-5654704Reactome: -MMU-5654706Reactome: -MMU-5654710Reactome: -MMU-5654712Reactome: -MMU-5654719Reactome: -MMU-5654720Reactome: -MMU-5654726Reactome: -MMU-5654727Reactome: -MMU-5654732Reactome: -MMU-5654733Reactome: -MMU-5658623Reactome: -MMU-5673001Reactome: -MMU-6811558Reactome: -MMU-8957275 |
| Cellular Localisation | SecretedSecretion Is Dependent On O-Glycosylation |
| Alternative Antibody Pair Names | Fibroblast Growth Factor 23 antibody pairFgf-23 antibody pairFgf23 antibody pair |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
