| Short Description : | Recombinant-Active-Mouse FGF2/bFGF-C-His protein was developed from e.coli and has a target region of C-His. For use in research applications. |
| Applications: | ELISA/WB |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity: | Measured in a cell proliferation assay using mouse fibroblast cells (NR6R‑3T3). The ED50 for this effect is 0.3-1.8 ng/mL. |
| Gene Symbol: | Fgf2 |
| Gene ID: | 14173 |
| Uniprot ID: | FGF2_MOUSE |
| Immunogen: | Mus musculus (Mouse) |
| Immunogen Region: | Ala11-Ser154 |
| Function | Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation. |
| Protein Name | Fibroblast Growth Factor 2Fgf-2Basic Fibroblast Growth FactorBfgfHeparin-Binding Growth Factor 2Hbgf-2 |
| Database Links | Reactome: R-MMU-109704Reactome: -MMU-1257604Reactome: -MMU-190322Reactome: -MMU-190370Reactome: -MMU-190372Reactome: -MMU-190373Reactome: -MMU-190375Reactome: -MMU-190377Reactome: -MMU-3000170Reactome: -MMU-5654219Reactome: -MMU-5654221Reactome: -MMU-5654227Reactome: -MMU-5654228Reactome: -MMU-5654687Reactome: -MMU-5654688Reactome: -MMU-5654689Reactome: -MMU-5654693Reactome: -MMU-5654695Reactome: -MMU-5654699Reactome: -MMU-5654700Reactome: -MMU-5654704Reactome: -MMU-5654706Reactome: -MMU-5654710Reactome: -MMU-5654712Reactome: -MMU-5654719Reactome: -MMU-5654720Reactome: -MMU-5654726Reactome: -MMU-5654727Reactome: -MMU-5654732Reactome: -MMU-5654733Reactome: -MMU-5658623Reactome: -MMU-5673001Reactome: -MMU-6811558Reactome: -MMU-9839397 |
| Cellular Localisation | SecretedNucleusExported From Cells By An Endoplasmic Reticulum (Er)/Golgi-Independent MechanismUnconventional Secretion Of Fgf2 Occurs By Direct Translocation Across The Plasma MembraneBinding Of Exogenous Fgf2 To Fgfr Facilitates Endocytosis Followed By Translocation Of Fgf2 Across Endosomal Membrane Into The CytosolNuclear Import From The Cytosol Requires The Classical Nuclear Import MachineryInvolving Proteins Kpna1 And Kpnb1As Well As Cep57 |
| Alternative Protein Names | Fibroblast Growth Factor 2 proteinFgf-2 proteinBasic Fibroblast Growth Factor proteinBfgf proteinHeparin-Binding Growth Factor 2 proteinHbgf-2 proteinFgf2 proteinFgf-2 protein |
Information sourced from Uniprot.org
