| Tissue Specificity | Detected in brain, eye and heart. In brain, the different isoforms display different patterns of expression. Expressed in brain and heart (at protein level). Isoform 3 is highly expressed in cardiac myocytes while isoform 1 is the most abundant in brain. |
| Post Translational Modifications | May be phosphorylated. |
| Function | Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. Regulates voltage-gated sodium channel transport and function. May also play a role in MAPK signaling. Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons. Isoform 1: Seems not to be involved in neuroblast polarization and migration but regulates axon branching. |
| Protein Name | Fibroblast Growth Factor 13Fgf-13Fibroblast Growth Factor Homologous Factor 2Fhf-2 |
| Database Links | |
| Cellular Localisation | Cell ProjectionFilopodiumGrowth ConeDendriteCell MembraneSarcolemmaCytoplasmNot SecretedLocalizes To The Lateral Membrane And Intercalated Disks Of MyocytesIsoform 1: NucleusIsoform 2: CytoplasmNucleusIsoform 3: Cytoplasm |
| Alternative ELISA Names | Fibroblast Growth Factor 13 ELISA kitFgf-13 ELISA kitFibroblast Growth Factor Homologous Factor 2 ELISA kitFhf-2 ELISA kitFgf13 ELISA kitFhf2 ELISA kit |
| output | |
Information sourced from Uniprot.org
