| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g |
| Gene Symbol: | Fgf21 |
| Gene ID: | 56636 |
| Uniprot ID: | FGF21_MOUSE |
| Immunogen: | Recombinant Mouse FGF-21 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Tyr30-Ser210) of mouse FGF-21 (Accession #NP_064397.1.) fused with and a 6×His tag at the C-terminus. |
| Immunogen Region: | Tyr30-Ser210 |
| Immunogen Sequence: | YPIPDSSPLLQFGGQVRQRY LYTDDDQDTEAHLEIREDGT VVGAAHRSPESLLELKALKP GVIQILGVKASRFLCQQPDG ALYGSPHFDPEACSFRELLL EDGYNVYQSEAHGLPLRLPQ KDSPNQDATSWGPVRFLPMP GLLHEPQDQAGFLPPEPPDV GSSDPLSMVEPLQGRSPSYA S |
| Function | Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity. |
| Protein Name | Fibroblast Growth Factor 21Fgf-21 |
| Database Links | Reactome: R-MMU-189200 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Fibroblast Growth Factor 21 proteinFgf-21 proteinFgf21 protein |
Information sourced from Uniprot.org
