| Tissue Specificity | Highly expressed in liver and spleen. |
| Post Translational Modifications | |
| Function | Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. |
| Protein Name | Ficolin-1Collagen/Fibrinogen Domain-Containing Protein 1Ficolin-AFicolin-AlphaM-Ficolin |
| Database Links | Reactome: R-MMU-166662Reactome: -MMU-166663Reactome: -MMU-2855086Reactome: -MMU-6798695 |
| Cellular Localisation | SecretedCell MembranePeripheral Membrane ProteinExtracellular SideFound On The Monocyte And Granulocyte Surface |
| Alternative ELISA Names | Ficolin-1 ELISA kitCollagen/Fibrinogen Domain-Containing Protein 1 ELISA kitFicolin-A ELISA kitFicolin-Alpha ELISA kitM-Ficolin ELISA kitFcn1 ELISA kitFcna ELISA kit |
| output | |
Information sourced from Uniprot.org
