| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.078ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description : | This FATP4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse serum, plasma, tissue homogenates, cell lysates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | Slc27a4 |
| Gene ID: | 26569 |
| Uniprot ID: | S27A4_MOUSE |
| Sample Type: | serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Most abundantly expressed in small intestine, brain, kidney, liver, skin and heart. In small intestine, expressed at high levels on the apical side of mature enterocytes. Highly expressed by the epithelial cells of the visceral endoderm and localized to the brush-border membrane of extraembryonic endodermal cells (at protein level). Expressed in the retinal pigment epithelium and in the retina (at protein level). Expressed in the retinal pigment epithelium and in the retina. |
| Post Translational Modifications | |
| Function | Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Probably involved in fatty acid transport across the blood barrier. Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones. |
| Protein Name | Long-Chain Fatty Acid Transport Protein 4 Fatp-4 Fatty Acid Transport Protein 4 Arachidonate--Coa Ligase Long-Chain-Fatty-Acid--Coa Ligase Solute Carrier Family 27 Member 4 Very Long-Chain Acyl-Coa Synthetase 4 Acsvl4 |
| Database Links | Reactome: R-MMU-804914 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein |
| Alternative ELISA Names | Long-Chain Fatty Acid Transport Protein 4 ELISA kit Fatp-4 ELISA kit Fatty Acid Transport Protein 4 ELISA kit Arachidonate--Coa Ligase ELISA kit Long-Chain-Fatty-Acid--Coa Ligase ELISA kit Solute Carrier Family 27 Member 4 ELISA kit Very Long-Chain Acyl-Coa Synthetase 4 ELISA kit Acsvl4 ELISA kit Slc27a4 ELISA kit Acsvl4 ELISA kit Fatp4 ELISA kit |
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Information sourced from Uniprot.org