Mouse ERRFI1 protein (Recombinant) (N-GST & C-His) (STJP011164)
SPECIFICATIONS
HostE.coli
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Mouse ERRFI1-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | Errfi1 |
| Gene ID | 74155 |
| Uniprot ID | ERRFI_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Ser329-Arg399 |
Additional Info
| Function | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development. |
| Protein Name | Erbb Receptor Feedback Inhibitor 1Mitogen-Inducible Gene 6 Protein HomologMig-6 |
| Database Links | |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideNucleusAssociated With The Plasma Membrane Of Basal Skin KeratinocytesTranslocates Into The Nucleus Of Differentiating Suprabasal Keratinocytes |
| Alternative Protein Names | Erbb Receptor Feedback Inhibitor 1 proteinMitogen-Inducible Gene 6 Protein Homolog proteinMig-6 proteinErrfi1 proteinMig6 protein |
Information sourced from Uniprot.org