Mouse ERRFI1 protein (Recombinant) (N-GST & C-His) (STJP011164)

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STJP011164
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse ERRFI1-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Errfi1
Gene ID: 74155
Uniprot ID: ERRFI_MOUSE
Immunogen Region: Ser329-Arg399
Immunogen: Mus musculus (Mouse)
Function Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development.
Protein Name Erbb Receptor Feedback Inhibitor 1
Mitogen-Inducible Gene 6 Protein Homolog
Mig-6
Cellular Localisation Cytoplasm
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Nucleus
Associated With The Plasma Membrane Of Basal Skin Keratinocytes
Translocates Into The Nucleus Of Differentiating Suprabasal Keratinocytes
Alternative Protein Names Erbb Receptor Feedback Inhibitor 1 protein
Mitogen-Inducible Gene 6 Protein Homolog protein
Mig-6 protein
Errfi1 protein
Mig6 protein

Information sourced from Uniprot.org

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