Mouse EREG protein (Recombinant) (N-HuFc-His) (STJP002955)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse EREG Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val56-Leu101 ) of Mouse EREG (Accession #NP_031976.1) fused with hFc tag at the N-terminus.
General Information
| Short Description | Recombinant-Mouse EREG-N-HuFc-His protein was developed in hek293 cells using the region Val56-Leu101 . For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured in a cell proliferation assay using Balb3T3 mouse fibroblast cells. The ED50 for this effect is 140.58-562.31 ng/mL, corresponding to a specific activity of 1.78×103~7.11×103 units/mg. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | Ereg |
| Gene ID | 13874 |
| Uniprot ID | EREG_MOUSE |
| Immunogen | Recombinant Mouse EREG Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val56-Leu101 ) of Mouse EREG (Accession #NP_031976.1) fused with hFc tag at the N-terminus. |
| Immunogen Region | Val56-Leu101 |
| Immunogen Sequence | QDGSVLSVPGPEGRPGFAGF PGPAGPKGNLGSKGERGSPG PKGEKGEPGSIFSPDGGALG PAQKGAKGEPGFRGPPGPYG RPGYKGEIGFPGRPGRPGMN GLKGEKGEPGDASLGFGMRG MPGPPGPPGPPGPPGTPVYD SNVFAESSRPGPPGLPGNQG PPGPKGAKGEVGPPGPPGQF PFDFLQLEAEMKGEKGDRGD AGQKGERGEPGGGGFFGSSL PGPPGPPGPPGPRGYPGIP |
Additional Info
| Function | Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation. |
| Protein Name | Proepiregulin Cleaved Into - EpiregulinEpr |
| Database Links | Reactome: R-MMU-1227986Reactome: -MMU-1236394Reactome: -MMU-1250196Reactome: -MMU-1250342Reactome: -MMU-1250347Reactome: -MMU-1257604Reactome: -MMU-177929Reactome: -MMU-179812Reactome: -MMU-180292Reactome: -MMU-180336Reactome: -MMU-182971Reactome: -MMU-1963640Reactome: -MMU-1963642Reactome: -MMU-212718Reactome: -MMU-5673001Reactome: -MMU-6785631Reactome: -MMU-6811558Reactome: -MMU-8847993Reactome: -MMU-8856825Reactome: -MMU-8856828Reactome: -MMU-8863795Reactome: -MMU-9009391 |
| Cellular Localisation | Epiregulin: SecretedExtracellular SpaceProepiregulin: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Proepiregulin Cleaved Into - Epiregulin proteinEpr proteinEreg protein |
Information sourced from Uniprot.org